The liver serves a vital function for the body. Not only does it metabolize most of the substance that pass through the body, it also synthesizes clotting factors, allowing for coagulation. It stores essential vitamins, and breaks down ammonia to a substance that can be excreted from the body. When the liver is damaged, one or all of these functions may stop and cause severe health issues.
A common cause of liver disease is alcoholism. Chronic and heavy drinking of alcohol will first lead to fatty liver disease, where globules of fat form in the liver and upsets the ability to filter appropriately. As heavy use continues, the liver cell begins to die, is replaced by fibrous tissues, or scars, causing a condition known as cirrhosis. This is one of the most common diseases seen in the alcoholic patient. Overall functions begin to stop, resulting in a condition known as hepatic encephalopathy, where ammonia is not excreted and the toxic levels cause confusion and can lead to death.
Poor diet can also lead to liver damage. The liver is a crucial point in the breakdown of fatty substances, so a diet chronically high in cholesterol taxes the liver's reserves and can complicate the process of breakdown. This is also another causative factor of fatty liver disease. As the liver is inundated with fats, it cannot produce enough bile to filter them all, resulting in damage.
Hepatitis refers to inflammation of the liver, which is often also caused by viruses, most notably hepatitis A, B, and C. These viruses attack the liver and kill the cells, resulting in fat deposits and plaque formation. Hepatitis A will clear up with time, but B and C are chronic and often lead to severe liver damage and death if left untreated. There is also autoimmune hepatitis, where the immune system attacks the liver without cause, but the damage is often mild and may heal when the condition resolves. Sclerosing cholangitis is another cause of hepatitis, and results from autoimmune attack on the bile ducts within and outside the liver.
Liver damage can also be drug induced, be it street drugs or medications, and caution is often used when dealing with a medication that has been known to cause hepatic toxicity. Blood tests are often performed to monitor the functions or enzymes in the liver, as well as clotting time since the liver, when functioning poorly, does not produce the right things to contribute to blood clotting. Certain medication may be discontinued should the liver show signs of malfunction, where continued use could lead to liver damage and liver cancer.
Liver damage carries with it abdominal pain and swelling, and is notoriously difficult to treat. However, by minimizing risk factors and reducing the amount of harmful substances that are introduced to the liver, liver damage can be prevented, and progression can be slowed.